In The Synthesis Of Many Organic Chemicals, Chloroacetyl Chloride Is One Of The Most Versatile Intermediates

Chloroacetyl Chloride
Chloroacetyl Chloride

A chlorinated acyl chloride is Chloroacetyl Chloride. It is a bifunctional compound that can be used as a chemical building block. It is synthesised industrially by carbonylation of methylene chloride, oxidation of vinylidene chloride, or the addition of chlorine to ketene. It can also be synthesised from chloroacetic acid and thionyl chloride, phosphorus pentachloride, or phosgene. Chlorinated acyl chloride is bifunctional in that the acyl chloride easily forms esters and amides, while the other end of the molecule can form other linkages, such as those with amines. The example of chlorinated acyl chloride being used in the synthesis of lidocaine is instructive.

Chloroacetyl Chloride is primarily used as an intermediate in the production of herbicides in the chloroacetanilide family, which includes metolachlor, acetochlor, alachlor, and butachlor; an estimated 100 million pounds are used annually. Some chlorinated acyl chloride is also used to make phenacyl chloride, which is also used to make tear gas. In a Friedel-Crafts acylation of benzene with an aluminium chloride catalyst, phenacyl chloride is synthesised.

In terms of revenue, Asia-Pacific dominated the Global Chloroacetyl Chloride Market in 2018, accounting for 39.5% of the total, followed by Latin America and North America, respectively.

When it reacts with other protic compounds such as amines, alcohols, and water, it produces hydrochloric acid, making it a lachrymator. The Occupational Safety and Health Administration has not established a regulated permissible exposure limit. The National Institute for Occupational Safety and Health, on the other hand, has established a recommended exposure limit of 0.05 ppm over an eight-hour work day.

Chloroacetyl Chloride is an excellent acylating agent, an important organic synthesis intermediate that is widely used in pesticides, dyes, additives, and other aspects, particularly pesticides, which are the most widely used and have the highest amount. Chloro acetyl chloride is widely used in agriculture, pharmaceuticals, pesticides, herbicides, active pharmaceutical ingredients, and other industries.

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