Inactivated Vaccine, Unlike Live but Attenuated Vaccines, are Made Comprised of Dead, or Inactivated, Viruses and Bacteria

Inactivated Vaccine
Inactivated Vaccine

Microorganisms (viruses, bacteria, and others) that have been killed by physical or chemical methods are used to make Inactivated Vaccine. These organisms are unable to spread disease since they have been killed.

An Inactivated Vaccine (also known as a killed vaccine) is made up of viral particles, bacteria, or other pathogens that have been grown in culture and then destroyed to remove their ability to cause disease. Live vaccinations, on the other hand, use germs that are still living (but are almost always attenuated, that is, weakened). In order to limit infectivity and thereby avoid infection from the vaccine, pathogens for inactivated vaccination are cultivated under controlled circumstances and killed.

Because inactivated pathogens elicit a weaker immune response than live pathogens, immunologic adjuvants and additional "booster" injections may be necessary for some vaccinations to achieve an adequate immune response. For persons who are typically healthy, attenuated vaccinations are often preferable because a single dose is often both safe and effective. Some people, however, are unable to get attenuated vaccines because the pathogen is too dangerous for them (for example, elderly people or people with immunodeficiency). Inactivated Vaccines can give protection for certain patients.

Inactivated Vaccines Against COVID-19 Pandemic

Currently, vaccine manufacturers around the world are racing to develop COVID-19 vaccinations. Many of the companies attempting this are using tried-and-true approaches, such as inactivated vaccinations. Because Inactivated Vaccines can be easily scaled up to large-scale production in many countries, they could be beneficial in the fight against COVID-19. The efficiency of inactivated vaccinations against COVID-19, on the other hand, is uncertain. In a mouse model, current studies with inactivated vaccinations, where inactivation was done using formaldehyde and ultraviolet light, were successful.

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